HEDS is part of the School of Health and Related Research (ScHARR) at the University of Sheffield. We undertake research, teaching, training and consultancy on all aspects of health related decision science, with a particular emphasis on health economics, HTA and evidence synthesis.

Tuesday, 19 March 2013

Intraoperative tests for detecting sentinel lymph node metastases in breast cancer – a NICE appraisal

From the NICE website:

“Draft guidance from NICE's Diagnostics Assessment Programme issued for consultation today recommends whole lymph node analysis using of the RD-100i OSNA system (Sysmex UK) as an option for detecting sentinel lymph node metastases in people with early invasive breast cancer who have a sentinel lymph node biopsy and in whom axillary lymph node dissection will be considered. The draft guidance also concludes that there is currently too much uncertainty associated with the evidence to recommend use of the Metasin test (TIB MOLBIOL) in routine NHS practice for the same indication.”

The Appraisal Group for this DAP was PenTAG, based at the University of Exeter Medical School.  However, the model for the appraisal was based on the HTA report "Positron emission tomography (PET) and magnetic resonance imaging (MRI) for the assessment of axillary lymph node metastases in early breast cancer" produced by HEDS. Consequently, collaboration with Katy Cooper and Yang Meng, especially around adaptation of the economic model, saw them named as authors on the Assessment Report.