HEDS is part of the School of Health and Related Research (ScHARR) at the University of Sheffield. We undertake research, teaching, training and consultancy on all aspects of health related decision science, with a particular emphasis on health economics, HTA and evidence synthesis.

Tuesday, 21 August 2018

HEDS 2 Day Course - Utility Data for Health Technology Assessment

Utility Data for Health Technology Assessment

2 day course:  Monday, 11th - Tuesday, 12th March 2019

NICE and similar agencies around the world are using QALYs, hence the need for health state utility data in their assessments of the cost effectiveness of health care interventions. This raises questions about the measurement of health, the valuation of health and whose values to use. It creates additional challenges for meeting the requirements of a ‘reference case’ set of methods that may not be appropriate in all circumstances.

What does the course deliver?

This course outlines the practical requirements of measuring utility and obtaining utility data for health technology assessment for agencies such as NICE and explores recent research in utilities including EQ-5D-5L valuation, measuring subjective well-being and condition specific preference-based measures.  It is delivered by a world leading team of experts in utility measurement.

Who will benefit from this course?

This course is for academics, government agencies, pharmacoeconomics and outcomes experts in industry and consultancies with an interest in the use of health state utility data. Basic prior knowledge of Patient Reported Outcomes, QALY's and health technology assessment is required.  For delegates without this prior knowledge (or who would like a re-cap), a free on-line introductory course will be provided prior to starting this course, which will take approximately 6-9 hours.

Book here
Image of Halifax Hall
Course Location - Halifax Hall

Course content

  • What are the key issues in obtaining health state utility values?
  • Does it matter which instruments are used?
  • What is the current NICE reference case and requirements in other jurisdictions?
  • When are EQ-5D and other generic measures not appropriate?
  • What utility instruments are available for children?
  • What are the latest development in EQ-5D including EQ-5D-5L valuation?
  • What should be done when EQ-5D and other generics are not appropriate or not available?
  • How can mapping be used to estimate utility values from disease specific measures?
  • Social value QALY weights
  • How do you search for utility values and what is the role of systematic reviews and meta-analysis of utility values?
  • How should utility values be incorporated into cost effectiveness models?
  • What is the role for wellbeing within HTA?
  • The development of condition specific measures (including the ReQol for mental health).
The course will consist of a mixture of presentations, group work, discussions and individual exercises.
Delegates are asked to provide their own laptop for the duration of the course.

Course Materials

A copy of the book 'Measuring and Valuing Health Benefits for Economic Evaluation' by Brazier, Ratcliffe, Salomon and Tsuchiya, is included in the course fee.
Course Materials will be provided via a Delegate Course Website approximately 2 weeks prior to the course start date. Hard copies of exercises will be provided throughout the course. Hard copies of powerpoint presentations will not be provided, but these can be printed by delegates before the start of the course via the Delegate Course Website.

Course Faculty

Dr Tessa Peasgood is the Course Leader for this 2 day short course

Monday, 20 August 2018

July’s CEAs.....

Our quick search for CEA’s published in July uncovered 44 articles.   In the right-hand column of this blog is a CEA Archive, which includes our CEA search results by month.  Below are those in our areas of interest.
  • Gamst-Klaussen T, Lamu AN, Chen G, Olsen JA. Assessment of outcome measures for cost-utility analysis in depression: mapping depression scales onto the EQ-5D-5L. BJPsych open. 2018;4(4):160-6.
  • Grustam AS, Severens JL, De Massari D, Buyukkaramikli N, Koymans R, Vrijhoef HJM. Cost-Effectiveness Analysis in Telehealth: A Comparison between Home Telemonitoring, Nurse Telephone Support, and Usual Care in Chronic Heart Failure Management. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 2018;21(7):772-82.
  • Leech AA, Kim DD, Cohen JT, Neumann PJ. Use and Misuse of Cost-Effectiveness Analysis Thresholds in Low- and Middle-Income Countries: Trends in Cost-per-DALY Studies. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 2018;21(7):759-61.
  • Zhou A, Yousem DM, Alvin MD. Cost-Effectiveness Analysis in Radiology: A Systematic Review. Journal of the American College of Radiology : JACR. 2018.

Thursday, 16 August 2018

Cochrane Collaboration Issue 7, 2018…

….is complete.  The website lists reviews and protocols.  Of note are……
  • Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes
  • Pembrolizumab monotherapy versus chemotherapy for treatment of advanced urothelial carcinoma with disease progression during or following platinum-containing chemotherapy. A Cochrane Rapid Review
  • Interventions for the eradication of meticillin-resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis
  • Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections
  • Nivolumab for adults with Hodgkin's lymphoma (a rapid review using the software RobotReviewer)
  • Psychological therapies for the treatment of mental disorders in low- and middle-income countries affected by humanitarian crises
Image of Cochrane Collaboration logo
© Cochrane

Wednesday, 15 August 2018

Website of the Month - Open Access Button

Open Access Button is exactly that, it is a button you click through your browser to find legal Open Access versions of research publications that may otherwise sit behind a paywall. It is a way of opening up research to global audiences that can have a positive effect on the world, especially when we think about health research. 

The website says:
"We urgently need trusted knowledge that’s fairly owned, created, and read. We’re addressing that by creating a family of library-aligned, open source tools built not-for-profit, but for-change. Our tools make it simpler to do research without subscriptions.
The project started when students got tired of hitting paywalls. Instead of accepting their frustration, they became inspired and took an idea to track the impact of paywalls to a hackday. The Open Access Button was launched in November 2013."

Image of Open Access Button Logo
Open Access Button

ScHARR Library Information Officer Sheldon Korpet said about the tool. 
"Open Access Button is a website which searches aggregate research repositories (like core.ac.uk) for journal articles that are free and legal to read. Simply paste the URL of the article you can't access and search to see if OA Button can find an open access version to read instantly. If the article isn't available OA Button ask the author to put a copy in a repository, so the tool only gets better with more users and searches." - Sheldon, Information Officer, ScHARR Library

Monday, 13 August 2018

Professor John Brazier discussing SF6D

ScHARR's Dean and Professor of Health Economics John Brazier discussing the SF6D - the most widely used measure of general health in clinical studies throughout the world.

It currently generates eight dimension scores and two summary scores for physical and mental health. Whilst such scores provide an excellent means for judging the effectiveness of health care interventions, they have only a limited application in economic evaluation because they are not based on preferences.

Thursday, 9 August 2018

NHS England Evidence Based Interventions Programme…

…consultation open on methods to be used.  Closes 28th September 2018.

Or in long form…
“Research evidence shows some interventions are not clinically effective or only effective when they are performed in specific circumstances. And as medical science advances, some interventions are superseded by those that are less invasive or more effective.

At both national and local levels, there is a general consensus that more needs to be done to ensure the least effective interventions are not routinely performed, or only performed in more clearly defined circumstances.

We have formed a new national collaboration with the Academy of Medical Royal Colleges, NICE, NHS Clinical Commissioners and NHS Improvement' GIRFT programme to turn this consensus into action - the Evidence Based Interventions Programme. This programme is counterpart to the items that should not be routinely prescribed in primary care programme launched in early 2018.

The proposals have been jointly developed by NHS England, NHS Clinical Commissioners, the Academy of Royal Medical Colleges, NICE and NHS Improvement's GIRFT programme in collaboration with the Royal Colleges and patient groups such as Healthwatch.

The proposals aim to reduce avoidable harm to patients, save precious professional time, help clinicians maintain their professional practice in line with the changing evidence base, create headroom for innovation and maximise value and avoid waste for patients and taxpayers.

We are publicly consulting on the design principles of the programme, the interventions we should target initially and proposed clinical criteria, the activity goals we should set and delivery actions, including proposed new terms in the NHS Standard Contract.
During the consultation period we are also hosting face to face events and a series of webinars (online meetings), to gather further clinical, professional and patient views. This will include patient and public events, webinars for CCGs and providers, an event co-hosted by Healthwatch England for their members, events jointly run with Age UK, NHSCC, the Health and Wellbeing Alliance, The NHS Youth Forum and Choices. Please contact us at england.ebinterventions@nhs.net to learn more about these events.

You can read more about the Evidence Based Interventions programme on the NHS England website.”

Wednesday, 8 August 2018

Latest publications from HEDS for July

Each month we explore what new publications have been produced by HEDS in collaboration with colleagues in ScHARR and further afield. Many of these are currently in press, so you can find much of our work in its open access form via our institutional repository. Tuck in here.

Cookson, R., Ali, S., Tsuchiya, A. & Asaria, M. (2018) E-learning and health inequality aversion: A questionnaire experiment. Health Economics. Available from: https://www.ncbi.nlm.nih.gov/pubmed/30033581.

Image of Health Economics Journal
© Wiley      
       Dodd, P. J. (2018) The pros of plurality for tuberculosis burden estimates. International Journal of Epidemiology. https://academic.oup.com/ije/advance-article-abstract/doi/10.1093/ije/dyy147/5053281 

       Keetharuth, D., Taylor Buck, E., Acquadro, C., Conway, K., Connell, J., Barkham, M., Carlton, J., Ricketts, T. N., Barber, R. & Brazier, J. E. (n.d.) Integrating qualitative and quantitative data in the development of outcome measures: the case of the Recovering Quality of Life (ReQoL) measures in mental health populations. International Journal of Environmental Research and Public Health. (Special Issue ‘Mental Health and Social Care and Social Interventions’). https://www.ncbi.nlm.nih.gov/pubmed/29949892

Kharroubi, S. & Rowen, D. L. (n.d.) Valuation of preference-based measures: Can existing preference data be used to select a smaller sample of health states? The European Journal of Health Economicshttps://www.ncbi.nlm.nih.gov/pubmed/29980950

Image of front cover of Journal of Genetic Counseling
© Springer
Pennington, R. M., Collins, B., Leigh, S., Martin, A. P., Owen, L., Fischer, A., Sumnall, H. & Bates, G. (2018) The cost-effectiveness of seven behavioural interventions to prevent drug misuse in vulnerable populations. International Journal of Drug Policy. 5742–50.  Available from: https://www.sciencedirect.com/science/article/pii/S0955395918300987.

Simpson, A., Ross, R., Porter, J., Dixon, S., Whitaker, M. J. & Hunter, A. (2018) Adrenal Insufficiency in Young Children: a Mixed Methods Study of Parents’ Experiences. Journal of Genetic Counseling. 1-12. https://www.ncbi.nlm.nih.gov/pubmed/29982889

Tummers, M., van Hoorn, R., Levering, C., Booth, A., van der Wilt, G. J. & Kievit, W. (n.d.) Optimal search strategies for identifying moderators and predictors of treatment effects in PubMed. Health Information & Libraries Journal. https://onlinelibrary.wiley.com/doi/full/10.1111/hir.12230

Monday, 6 August 2018

HEDS PhD Focus - Hannah Penton - The validity and acceptability of existing measures of health and social care related quality of life and wellbeing in older people.

Image of Hannah Penton
Hannah Penton
On the HEDS Blog we like to regularly highlight our talented PhD students and the excellent research they are undertaking in Sheffield. This time it is the turn of Hannah Penton to talk about her work.

My name is Hannah Penton and I am in the third year of my PhD in HEDS. Prior to starting my PhD, I graduated from the MSc Health Economics and Decision Modelling, also in ScHARR. My PhD investigates the validity and acceptability of existing measures of health and social care related quality of life and wellbeing in older people. This includes psychometric analysis of the EQ-5D-5L, SF-12, ASCOT, WEMWBS and ONS-4 using item response theory and differential item functioning methods and qualitative investigation of the content validity of a selection of these measures in older people.

My PhD is part of a White Rose network (match funded by CLAHRC), alongside PhD students in Leeds and York. My supervisors, Dr Tracey Young, Christopher Dayson and Dr Claire Hulme, are spread across three institutions (University of Sheffield, Sheffield Hallam and University of Leeds). Within the network our PhDs investigate related topics and we have regular joint meetings with all of our supervisors to discuss progress and issues, which can be of great help. I think networks such as these offer great opportunities for students in terms of wider training and support networks and I hope more PhDs can be run this way in the future.

Friday, 3 August 2018

NHS England and the lack of any economics

Image of piggy bank and coins
CC BY 2.0 Alfy http://bit.ly/2AuUXTF
Does economics have too much influence on the NHS? Judging by the current Clinical Commissioning Policy proposition for Gemcitabine and Capecitabine following surgery for pancreatic cancer, this is unlikely to be the case.

The proposition is open for consultation until 19th August and no economic evidence is considered.  Or have we missed something?

Thursday, 2 August 2018

New Health Technology Assessment report - ultrasound joint examination for monitoring synovitis in rheumatoid arthritis

HEDS have lead on a new HTA Report: What is the added value of ultrasound joint examination for monitoring synovitis in rheumatoid arthritis and can it be used to guide treatment decisions? A systematic review and cost-effectiveness analysis

Dr Emma Simpson, Dr Emma Everson Hock, Professor Matt Stevenson, Dr Ruth Wong, Naila Dracup and Professor Allan Wailoo worked alongside colleagues from Leeds, Liverpool and Southampton.

Image of HTA report webpage
Limited evidence suggests ultrasound monitoring of synovitis could provide an effective approach to selecting rheumatoid arthritis patients for biologic treatment tapering or escalation-avoidance.