HEDS is part of the School of Health and Related Research (ScHARR) at the University of Sheffield. We undertake research, teaching, training and consultancy on all aspects of health related decision science, with a particular emphasis on health economics, HTA and evidence synthesis.

Wednesday, 16 August 2017

July’s CEAs.....

Our quick search for CEA’s published in July uncovered 40 articles.   In the right-hand column of this blog is a CEA Archive, which includes our CEA search results by month.  Below are those in our areas of interest.
  • Bansback N, Phibbs CS, Sun H, O'Dell JR, Brophy M, Keystone EC, et al. Triple Therapy Versus Biologic Therapy for Active Rheumatoid Arthritis: A Cost-Effectiveness Analysis. Annals of internal medicine. 2017;167(1):8-16.
  • Clarke M, Fursse J, Connolly N, Sharma U, Jones R. Evaluation of the National Health Service (NHS) Direct Pilot Telehealth Program: Cost-Effectiveness Analysis. Telemedicine journal and e-health : the official journal of the American Telemedicine Association. 2017.
  • Goto D, Shih YT, Lecomte P, Olson M, Udeze C, Park Y, et al. Regression-Based Approaches to Patient-Centered Cost-Effectiveness Analysis. PharmacoEconomics. 2017;35(7):685-95.

Monday, 14 August 2017

July’s CEAs, systematic reviews and epidemiological models in LMICs

To help us keep on top of current research in low and middle-income countries, we are running a monthly search of research that is aligned to our core research interests.  It's a simple search strategy, with those published in April that are most aligned to our interests listed below.  The full list of articles is kept in our "Searches archive" in the right-hand column.
  • Onyedum CC, Alobu I, Ukwaja KN. Prevalence of drug-resistant tuberculosis in Nigeria: a systematic review and meta-analysis. PloS one. 2017;12(7):e0180996.
  • Pecenka C, Parashar U, Tate JE, Khan JAM, Groman D, Chacko S, et al. Impact and cost-effectiveness of rotavirus vaccination in Bangladesh. Vaccine. 2017;35(32):3982-7.
  • Vassall A, Siapka M, Foster N, Cunnama L, Ramma L, Fielding K, et al. Cost-effectiveness of Xpert MTB/RIF for tuberculosis diagnosis in South Africa: a real-world cost analysis and economic evaluation. The Lancet Global health. 2017;5(7):e710-e9.

Thursday, 10 August 2017

NHS England consultations…

… on Specialised Services clinical commissioning policies for:
  • Mechanical thrombectomy for acute ischaemic stroke
  • Balloon Pulmonary Angioplasty for chronic thromboembolic pulmonary hypertension
  • Keratoprosthesis for corneal blindness
More details here.

Wednesday, 9 August 2017

Hello Laos!



The HEDS Blog has had its first visitor from Laos....the 148th country to visit us.

Monday, 7 August 2017

NICE position statement on EQ-5D-5L

“Currently the 5L valuation set is not recommended for use. Companies, academic groups, and others preparing evidence submissions for NICE should:
  • Use the 3L valuation set for reference-case analyses.
  • If data were gathered using the EQ-5D-5L descriptive system, reference-case analyses should calculate utility values by mapping the 5L descriptive system data onto the 3L valuation set.
  • If analyses use data gathered using both EQ-5D-3L and EQ-5D-5L descriptive systems, use the 3L valuation set to derive all utility values, with 5L mapped onto 3L where needed.
  • Whilst several mapping functions are available (Hernandez Alava et al. 2017), for consistency with the current guide to the methods of technology appraisal, the mapping function developed by van Hout et al. (2012) should be used for reference-case analyses.
  • NICE supports sponsors of prospective clinical studies continuing to use the 5L version of EQ-5D descriptive system to collect data on quality of life.
NICE plans to review this statement in August 2018.”

Further explanation is available here.

Thursday, 3 August 2017

Advanced Simulation Methods - Three Day Course - 27th-29th November

Image of Halifax Hall Hotel
© Halifax Hall 
HEDS in conjunction with ScHARR's Short Course Unit are running a three day course In Sheffield between 27th and 29th November. Dr Hazel Squires, Professor Matt Stevenson and Dr Sarah Davis will facilitate the workshop held at the superb Halifax Hall Hotel and Conference Centre. 
Background to the course 
Within healthcare decision making, cohort Markov models and decision trees are frequently used. However, in some situations these are not the most appropriate modelling methods. This course provides an in-depth review of individual-level simulation rationale, techniques and methodologies with a particular focus on discrete event simulation and its practical application to inform healthcare decision making. From the fundamentals of a basic model the course will progress to modelling complex systems, verification and interpreting output, as well as exploring alternative software options.
This course aims to provide participants with the skills required to be able to undertake simulation projects to a professional level. It will be both theoretically-based and practically-based, with the use of the Simul8 software package. It will cover the use of discrete-event simulation to assess the impact of alternative options within a local system with resource constraints and the use of patient-level simulation for health economic modelling.
This course is primarily for health economic modellers who want to broaden their skill base, as well as healthcare decision makers who would like to understand more about patient-level simulation and when it might be useful. Participants must have a basic level of knowledge of health economic modelling in order to follow the course. The course will consist of a mixture of presentations and practical use of Simul8, both following the lecturer and within individual exercises.
Participants are asked to provide their own laptop for the duration of the course.

To book a place go here

Tuesday, 1 August 2017

Latest Publications from HEDS in July


Ara, R. M. and brazier, J. (no date) ‘Estimating HSUVs For Comorbidities’, PharmacoEconomics. Adis.

Ara, R. M., brazier, J. and azzabi-zouraq, I. (no date) ‘The Use of Health State Utility Values In Decision Models’, PharmacoEconomics. Adis.

Image of PhamacoEconomics journal
PharmacoEconomics
Ara, R. M., brazier, J., peasgood, T. and paisley, S. (no date) ‘The identification, review and synthesis of HSUV’s from the literature’, PharmacoEconomics. Adis.

Ara, R. M., brazier, J. and young, T. (no date) ‘Recommended Methods For The Collection of HSUV Evidence In Clinical Studies’, PharmacoEconomics. Adis.

Ara, R. M., Peasgood, T., Mukuria, C., Chevrou-Severac, H., Rowen, D., Azzabi-Zouraq, I., Paisley, S., van Hout, B. and Brazier, J. (no date) ‘Sourcing and using appropriate health state utility values in economic models in health care’, PharmacoEconomics. Adis.

Carlton, J., Elliott, J., Rowen, D., Stevens, K., Basarir, H., Meadows, K. and Brazier, J. (no date) ‘Developing a questionnaire to determine the impact of self-management in diabetes: giving people with diabetes a voice’, Health and Quality of Life Outcomes. BioMed Central.

Cowdell, F., Booth, A. and Appleby, B. (2017) ‘Knowledge mobilisation in bridging patient-practitioner-researcher boundaries: a systematic integrative review protocol’, Journal Of Advanced Nursing. England. doi: 10.1111/jan.13378.

Image of Journal of Health Informatics front cover
Journal of Health Economics
Hernandez, M. and Pudney, S. (no date) ‘Econometric modelling of multiple self-reports of health states: The switch from EQ-5D-3L to EQ-5D-5L in evaluating drug therapies for rheumatoid arthritis’, Journal of Health Economics. Elsevier.

Maidment, I., Booth, A., Mullan, J., McKeown, J., Bailey, S. and Wong, G. (2017) ‘Developing a framework for a novel multi-disciplinary, multi-agency intervention(s), to improve medication management in community-dwelling older people on complex medication regimens (MEMORABLE)--a realist synthesis.’, Syst Rev. England, 2017(6). doi: 10.1186/s13643-017-0528-1.

Möller, J., Davis, S., Stevenson, M. and Caro, J. J. (2017) ‘Validation of a DICE Simulation Against a Discrete Event Simulation Implemented Entirely in Code.’, Pharmacoeconomics. New Zealand. doi: 10.1007/s40273-017-0534-0.

Rehfuess, E. A., Booth, A., Brereton, L., Burns, J., Gerhardus, A., Mozygemba, K., Oortwijn, W., Pfadenhauer, L. M., Tummers, M., van der Wilt, G.-J. and Rohwer, A. (2017) ‘Towards a taxonomy of logic models in systematic reviews and health technology assessments: a priori, staged and iterative approaches.’, Research Synthesis Methods. England. doi: 10.1002/jrsm.1254.

Image of Journal of Epidemiology and Community Health front cover
Journal of Epidemiology
& Community Health
Salleh, S., Thokala, P., Brennan, A., Hughes, R. and Dixon, S. (2017) ‘Discrete Event Simulation-Based Resource Modelling in Health Technology Assessment’, PharmacoEconomics. doi: 10.1007/s40273-017-0533-1.

Squires, H. Y., Poku, E., Bermejo, I., Cooper, K., Stevens, J., Hamilton, J., Wong, R., Denniston, A., Pearce, I. and Quhill, F. (no date) ‘A systematic review and economic evaluation of adalimumab and dexamethasone for treating non-infectious intermediate, posterior or panuveitis in adults’, Health technology assessment (Winchester, England). NIHR Health Technology Assessment Programme.

de Vocht, F., Tilling, K., Pliakas, T., Angus, C., Egan, M., Brennan, A., Campbell, R. and Hickman, M. (no date) ‘The intervention effect of local alcohol licensing policies on hospital admission and crime: a natural experiment using a novel Bayesian synthetic time-series method’, Journal of Epidemiology and Community Health. England: BMJ Publishing Group. doi: 10.1136/jech-2017-208931.


Friday, 28 July 2017

Using DICE for modelling cost-effectiveness

We have previously given you news about NICE TSD 15 Patient-level simulation, but we didn’t tell you about an extension to it that looked at the replicability of simulations using the Discretely Integrated Condition Event (DICE) tool.  Well…that work has now been published in Pharmacoeconomics (reference below) and all the models and code used in that have been added to the TSD website here.

Moller J, Davis S, Stevenson M, Cairo J. (2017). Validation of a DICE Simulation Against a Discrete Event Simulation Implemented Entirely in Code.  Pharmacoeconomics, July 2017

Image: Dice by Victoria Pickering


Wednesday, 26 July 2017

HEDS contributes to new report on liver disease and alcohol consumption

A new report published by the Foundation for Liver Research and endorsed by the Lancet Commission on Liver Disease includes new estimates from the Sheffield Alcohol Research Group (SARG) (which contains members of HEDS) of the burden that alcohol places on the NHS and society. The report was featured on the front page of the Guardian newspaper on Monday 24th July, 2017.

The figures used in the report come from the Sheffield Alcohol Policy Model, a complex behavioural and epidemiological simulation model which combines data on patterns of alcohol consumption and purchasing, current rates of harm for 43 different alcohol-related health conditions, evidence on the relationship between prices and purchasing, and epidemiological evidence on the links between drinking at different levels and risks of harm.

The numbers show that alcohol is estimated to cause 35 deaths and 2.300 hospital admissions a day in England, and over the next 5 years this will cost the NHS almost £17billion at a time when healthcare resources and budgets are already being stretched. This research also highlights the potential for policies such as a Minimum Unit Price for alcohol to reduce this burden.


Image of alcohol deaths graph
Estimated deaths attributable to alcohol over next 5 years
This report comes out just as the UK Supreme Court is hearing the final stage in a lengthy court battle between the Scottish Government and the Scotch Whisky Association about the legality of Scotland's efforts to introduce a Minimum Unit Price for alcohol.

Evidence from SARG and the Sheffield Model has formed an integral part of the court case, highlighting that the policy would effectively target the heaviest drinkers and have a positive effect on socioeconomic inequalities in health. The court's judgement is expected to be delivered in the Autumn, with a host of other countries, including Wales and Ireland, looking on. Both countries have announced their intention to introduce a Minimum Unit price, supported by SARG modelling, however this seems certain to be conditional on the Supreme Court ruling that the policy is not in breach of EU law.

The report can be viewed here

Guardian article featuring SARG's work.

Tuesday, 25 July 2017

MSc Economics and Health Economics dissertations……

….are about to start.  Topics include
  • Cost-effectiveness of remifentanil intravenously administered patient-controlled analgesia versus pethidine intramuscular injection for pain relief in labour. 
  • Cost-effectiveness of a telehealth app to improve access to specialist care for patients with motor neurone disease
  • Estimating regional differences in incidence of cancer stratified by tumour type and patient characteristics
  • Labour market over-education and cognitive decline specific to preclinical dementia
  • The effects of a partner's heavy drinking on an individual's wellbeing.
Image: Out Drinking by Chris RubberDragon

  • The impact of father's work place pressure on children's well-being: a case study in the UK
  • Public preferences on access to mental health treatment with regards to employment status