HEDS is part of the School of Health and Related Research (ScHARR) at the University of Sheffield. We undertake research, teaching, training and consultancy on all aspects of health related decision science, with a particular emphasis on health economics, HTA and evidence synthesis.

Thursday, 27 April 2017

Cancer Research Senior Non-Clinical Fellowship in ScHARR in…

…Health Economics, Mathematical Modelling, Medical Statistics or Medical Physics, supported by Yorkshire Cancer Research.

We wish to attract up to 10 high quality candidates to take up senior non-clinical research fellowships.  Appointees should focus on clinical and translational aspects of cancer research within the following priority themes that align closely with the Yorkshire Cancer Research (YCR) research strategy:
  • Lung cancer
  • Improving clinical outcomes in common malignancies
  • Improved health and wellbeing with and beyond cancer
  • Early diagnosis and access to treatment
These new appointments will link with the University of Sheffield (UoS) Research Centres, thereby providing a connected research infrastructure with the dual aims of reducing cancer mortality and improving the experience of living with or after a cancer diagnosis. Each appointee will receive a generous start-up package to enable rapid initiation of internationally competitive research.

Job Reference Number: UOS015963
Contract Type: Fixed-term for 5 years
Senior Non-Clinical Fellowship, Grade 8/9 £39,324 to £55,998 per annum
Closing Date: 29th May 2017

You can view details of how to apply here.  For an informal discussion about the posts, please contact Professor Jim Chilcott (j.b.chilcott@sheffield.ac.uk) or Dr Paul Tappenden (p.tappenden@sheffield.ac.uk) at ScHARR.

Image: job by Ben Thompson

Tuesday, 25 April 2017

Monday, 24 April 2017

March’s CEAs, systematic reviews and epidemiological models in LMICs

To help us keep on top of current research in low and middle-income countries, we are running a monthly search of research that is aligned to our core research interests.  It's a simple search strategy, with those published in March that are most aligned to our interests listed below.  The full list of articles is kept in our "Searches archive" in the right-hand column.
  • Gesesew HA, Tesfay Gebremedhin A, Demissie TD, Kerie MW, Sudhakar M, Mwanri L. Significant association between perceived HIV related stigma and late presentation for HIV/AIDS care in low and middle-income countries: A systematic review and meta-analysis. PloS one. 2017;12(3):e0173928.
  • Lai YS, Zhou XN, Pan ZH, Utzinger J, Vounatsou P. Risk mapping of clonorchiasis in the People's Republic of China: A systematic review and Bayesian geostatistical analysis. PLoS neglected tropical diseases. 2017;11(3):e0005239.
  • Lee TH, Kim W, Shin J, Park EC, Park S, Kim TH. Strategic Distributional Cost-Effectiveness Analysis for Improving National Cancer Screening Uptake in Cervical Cancer: A Focus on Regional Inequality in South Korea. Cancer research and treatment : official journal of Korean Cancer Association. 2017.
  • Mezei AK, Armstrong HL, Pedersen HN, Campos NG, Mitchell SM, Sekikubo M, et al. Cost-effectiveness of cervical cancer screening methods in low- and middle-income countries: A systematic review. International journal of cancer. 2017.
  • Tian M, Zhang J, Luo R, Chen S, Petrovic D, Redfern J, et al. mHealth Interventions for Health System Strengthening in China: A Systematic Review. JMIR mHealth and uHealth. 2017;5(3):e32.
Image: search by Pleuntje


Wednesday, 19 April 2017

March’s CEAs.....

Our quick search for CEA’s published in February uncovered 43 articles.   In the right-hand column of this blog is a CEA Archive, which includes our CEA search results by month.  Below are those in our areas of interest.
  • Clarke CS, Hunter RM, Shemilt I, Serra-Sastre V. Multi-arm Cost-Effectiveness Analysis (CEA) comparing different durations of adjuvant trastuzumab in early breast cancer, from the English NHS payer perspective. PloS one. 2017;12(3):e0172731.
  • Hernandez L, Guo S, Toro-Diaz H, Carroll S, Syed Farooq SF. Peginterferon beta-1a versus other self-injectable disease-modifying therapies in the treatment of relapsing-remitting multiple sclerosis in Scotland: a cost-effectiveness analysis. Journal of Medical Economics. 2017;20(3):228-38.
  • Lee TH, Kim W, Shin J, Park EC, Park S, Kim TH. Strategic Distributional Cost-Effectiveness Analysis for Improving National Cancer Screening Uptake in Cervical Cancer: A Focus on Regional Inequality in South Korea. Cancer research and treatment : official journal of Korean Cancer Association. 2017.
  • McGuffin M, Merino T, Keller B, Pignol JP. Who Should Bear the Cost of Convenience? A Cost-effectiveness Analysis Comparing External Beam and Brachytherapy Radiotherapy Techniques for Early Stage Breast Cancer. Clinical oncology (Royal College of Radiologists (Great Britain)). 2017;29(3):e57-e63.
  • Padula WV, Millis MA, Worku AD, Pronovost PJ, Bridges JF, Meltzer DO. Individualized cost-effectiveness analysis of patient-centered care: a case series of hospitalized patient preferences departing from practice-based guidelines. Journal of Medical Economics. 2017;20(3):288-96.

Monday, 17 April 2017

MSc International Health Technology Assessment

Dissertation topics have now been agreed for the summer.  All dissertations for the MSc IHTAP&R are the development of clinical and economic evidence in support of value propositions relating to specific treatments.  Conditions covered this year include:
  • Alzheimer’s disease
  • Duchenne muscular dystrophy
  • Acute Myeloid Leukemia
  • Severe asthma
  • Childhood cerebral adrenoleukodystrophy (CALD) and X-linked adrenoleukodystrophy (ALD)
  • End-stage critical limb ischaemia.
Further details of the MSc IHTAP&R are available here.

Thursday, 13 April 2017

New NICE documentation

The fast track and budget impact threshold changes are now in operation.  The documentation relating to these changes are now on the NICE website, including:
  • Joint consultation document
  • NICE Board paper
  • Consultation analysis
  • Procedure for varying the funding requirement to take account of net budget impact
  • Assessing resource impact process manual: technology appraisals and highly specialised technologies
  • Fast track appraisal - Addendum to the Guide to the Processes of Technology Appraisal
  • Cost comparison - Addendum to the Guide to the methods of Technology Appraisal
Existing submission templates have also been updated to address the implementation of the changes.

Image: Nice Ball Bearings by Lenore Edman


Wednesday, 12 April 2017

ISOQOL Co-chair

Anju Keetharuth has been appointed the new Co-chair of the ISOQOL UK & Ireland Special Interest
Group (SIG). She is will be starting her term in October 2017 succeeding John Brazier, working alongside Elizabeth Gibbons from the University of Oxford.

The overall aim of the SIG is to promote research into use of PROMS in the UK and in addition meet the aim of ISOQOL ‘to advance the scientific study of health-related quality of life and other patient-centered outcomes to identify effective interventions, enhance the quality of health care and promote the health of populations’.

One of the current initiatives of the SIG is the 2nd UK PROMs conference at the University of Oxford on June 8th 2017 following the first successful conference hosted by the University of Sheffield last year.

Image: Anju Keetharuth by University of Sheffield

Monday, 10 April 2017

CWiPP Keynote Lecture by Paul Dolan

Who: Prof Paul Dolan, Professor of Behavioural Science, London School of Economics
When: Wed 24 May 2017, 1730-1830
Where: Lecture Theatre 4, The Diamond, University of Sheffield
What: “The narrative trap”

Paul says: "In my follow up to Happiness by Design, I will explore some of the main social stories we are told about how we ought to live our lives. I will seek to show that these narratives actually cause more harm than good to our happiness. This talk is very much work in progress. I will benefit from getting your comments, and I hope you will learn something too."

Why: Paul wrote the questions that are currently being used by the Office for National Statistics to monitor national wellbeing and is also responsible for producing the MINDSPACE report for the UK Cabinet Office, which he uses widely in consulting with public sector and corporate clients. Much of his work has been inspired by his time working alongside Nobel Laureate Daniel Kahneman at Princeton University and Mark Deverill at the University of Sheffield.

How: Please register here.

Image: TO HAPPiNESS by Kayla Nicole


Wednesday, 5 April 2017

HEDS in the media - January to March 2017

A lot of the research that ScHARR and HEDS conducts gains media and online attention. As per the last few quarterly periods we have taken a quick look at some the attention using Altmetrics to see what has been said about our work and how far and wide it has reached on social media channels.


Dr Chris Carroll's piece in The BMJ 'Qualitative evidence synthesis to improve implementation of clinical guidelines' received an awful lot of attention across Twitter as 279 Tweets were sent as a result of the article. Richard Lehman's popular journal round up in the BMJ Opinion Blog wrote saying; "here at last is a very good BMJ analysis piece making the point clearly and trenchantly."


As you can imagine, a piece of research by HEDS with the title: 'Complimentary and Alternative Medicine for Management of Premature Ejaculation' was always going to gain some media attention. The Mail Online, Fox News and Medscape all gave coverage to this research. As did Edzard Ernst with his own tabloid headlined article; "Coming sooner or later – alternative therapies for premature ejaculation". ScienceBlogs also picked up on the article which lead to dozens of comments, not all of them puerile.

Since January our research has been picked up in 17 news stories, featured in 10 blogs and Tweeted about somewhere in the region of 500 times; with 140 Tweets (how apt) on the 17th January when it was mostly the aforementioned research by Dr Carroll being shared.

Much of our work around alcohol pricing was mentioned in the release of The House of Commons Briefing Paper 'Alcohol: Minimum Pricing'. The Lancet paper 'Effects of minimum unit pricing for alcohol on different income and socioeconomic groups: a modelling study' from 2014 was cited in the Parliamentary paper published in January this year.

Here is the Altmetric data from the first three months of 2017.


Image of HEDS altmetric data from first quarter of 2017
HEDS Altmetric data from first quarter of 2017

Tuesday, 4 April 2017

And the Value in Health Paper of the Year Award goes to…..

…Sabine Grimm, Simon Dixon and John Stevens for “When Future Change Matters: Modeling Future Price and Diffusion in Health Technology Assessments of Medical Devices” Value Health 2016;19;6:720-726.

The paper was produced during Sabine’s PhD studies that she undertook within HEDS.  Sabine will be receiving the award prior to the Second Plenary Session of the ISPOR 22nd Annual International Meeting, May 20-24, 2017, at the Sheraton Boston Hotel and the John B. Hynes Veterans Memorial Convention Center Boston, MA, USA.

Image: Greetings from Boston, Mass. [front] by Boston Public Library