HEDS is part of the School of Health and Related Research (ScHARR) at the University of Sheffield. We undertake research, teaching, training and consultancy on all aspects of health related decision science, with a particular emphasis on health economics, HTA and evidence synthesis.

Thursday, 20 September 2018

August’s CEAs, systematic reviews and epidemiological models in LMICs

To help us keep on top of current research in low and middle-income countries, we are running a monthly search of research that is aligned to our core research interests.  It's a simple search strategy, with those published last month that are most aligned to our interests listed below.  The full list of articles is kept in our "Searches archive" in the right-hand column.
  • Allen LN, Townsend N, Williams J, Mikkelsen B, Roberts N, Wickramasinghe K. Socioeconomic status and alcohol use in low- and lower-middle income countries: A systematic review. Alcohol (Fayetteville, NY). 2018;70:23-31.
  • Balhara KS, Bustamante ND, Selvam A, Winders WT, Coker A, Trehan I, et al. Bystander Assistance for Trauma Victims in Low- and Middle-Income Countries: A Systematic Review of Prevalence and Training Interventions. Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors. 2018:1-46.
  • Liu Y, Kong Q, Yuan S, van de Klundert J. Factors influencing choice of health system access level in China: A systematic review. PloS one. 2018;13(8):e0201887.
  • Sun L, Legood R, Sadique Z, Dos-Santos-Silva I, Yang L. Cost-effectiveness of risk-based breast cancer screening programme, China. Bulletin of the World Health Organization. 2018;96(8):568-77.

Tuesday, 18 September 2018

August’s CEAs.....

We’ve completed our quick search for CEA’s published last month.   In the right-hand column of this blog is a CEA Archive of all records.  Below are those in our areas of interest.
  • Buse S, Hach CE, Klumpen P, Schmitz K, Mager R, Mottrie A, et al. Cost-effectiveness analysis of robot-assisted vs. open partial nephrectomy. The international journal of medical robotics + computer assisted surgery : MRCAS. 2018;14(4):e1920.
  • Cavany SM, Vynnycky E, Anderson CS, Maguire H, Sandmann F, Thomas HL, et al. Should NICE reconsider the 2016 UK guidelines on TB contact tracing? A cost-effectiveness analysis of contact investigations in London. Thorax. 2018.
  • Garcia-Lorenzo B, Rivero-Santana A, Vallejo-Torres L, Castilla-Rodriguez I, Garcia-Perez S, Garcia-Perez L, et al. Cost-effectiveness analysis of real-time continuous monitoring glucose compared to self-monitoring of blood glucose for diabetes mellitus in Spain. Journal of evaluation in clinical practice. 2018;24(4):772-81.
  • Leurent B, Gomes M, Faria R, Morris S, Grieve R, Carpenter JR. Sensitivity Analysis for Not-at-Random Missing Data in Trial-Based Cost-Effectiveness Analysis: A Tutorial. PharmacoEconomics. 2018;36(8):889-901.
  • McKay AJ, Hogan H, Humphries SE, Marks D, Ray KK, Miners A. Universal screening at age 1-2 years as an adjunct to cascade testing for familial hypercholesterolaemia in the UK: A cost-utility analysis. Atherosclerosis. 2018;275:434-43.
  • Souche R, Herrero A, Bourel G, Chauvat J, Pirlet I, Guillon F, et al. Robotic versus laparoscopic distal pancreatectomy: a French prospective single-center experience and cost-effectiveness analysis. Surgical endoscopy. 2018;32(8):3562-9.

Monday, 17 September 2018

DHSC consultation on gluten-free foods on prescription

The government has decided to restrict gluten-free (GF) prescribing to bread and mixes only, following the March 2017 consultation on the availability of gluten-free foods on NHS prescription.

This new consultation provides the draft regulations that will allow this and describes what will be done to apply the changes.

There is a cost-benefit analysis (referred to an an Impact Assessment) of the various options.  The key assumptions are the cost-effectiveness of GF foods and the propensity of individuals to continue buying GF foods…whilst a withdrawal of all foods has some scenarios with negative NPVs, the proposed (partial) withdrawal has none.

As far as I can see, health inequalities are not evaluated.

Further details are available here.  It closes on the 1st October.

Friday, 14 September 2018

Latest publications from HEDS for August

Once again we explore what new publications have been produced by HEDS in collaboration with colleagues in ScHARR. Many of these are currently in press, so you can find much of our work in its open access form via our institutional repository. Tuck in here.

Angus, C., Henney, M., Webster, L. & Gillespie, D. (n.d.) Alcohol-attributable diseases and dose-response curves for the Sheffield Alcohol Policy Model version 4.0. [Online]  Available from: https://ndownloader.figshare.com/files/12402395.

Bhattacharya, A., Angus, C., Pryce, R., Holmes, J., Brennan, A. & Meier, P. S. (2018) How dependent is the alcohol industry on heavy drinking in England? Addiction. [Online]

Image of BMJ Open logo
                         BMJ Open                   
       Catto, J. W. F., Khetrapal, P., Ambler, G., Sarpong, R., Khan, M. S., Tan, M., Feber, A., Dixon, S., Goodwin, L., Williams, N. R., McGrath, J., Rowe, E., Koupparis, A., Brew-Graves, C. & Kelly, J. D. (2018) Robot-assisted radical cystectomy with intracorporeal urinary diversion versus open radical cystectomy (iROC): protocol for a randomised controlled trial with internal feasibility study. BMJ Open. [Online] 8 (8), e020500.  Available from: https://www.ncbi.nlm.nih.gov/pubmed/30093510.

       Collaborators, G. B. D. 2016 A. (2018) Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. [Online]  Available from: https://www.ncbi.nlm.nih.gov/pubmed/30146330.

Cooper, C., Booth, A., Varley-Campbell, J., Britten, N. & Garside, R. (2018) Defining the process to literature searching in systematic reviews: A literature review of guidance and supporting studies. BMC Medical Research Methodology. [Online] 18 (1), .

Image of The Lancet Global Health logo
The Lancet Global Health
Dodd, P. J., Yuen, C. M., Becerra, M. C., Revill, P., Jenkins, H. E. & Seddon, J. A. (n.d.) The potential impact of household contact management on childhood tuberculosis: a mathematical modelling study. The Lancet Global Health

Finch, A. P., Brazier, J. E. & Mukuria, C. (2018) Selecting Bolt-On Dimensions for the EQ-5D: Examining Their Contribution to Health-Related Quality of Life. Value in Health

De Freitas, L., Goodacre, S., O’Hara, R., Thokala, P. & Hariharan, S. (2018) Interventions to improve patient flow in emergency departments: an umbrella review. Emergency Medicine Journal. [Online]  Available from: https://www.ncbi.nlm.nih.gov/pubmed/30093379.

Goodacre, S., Horspool, K., Shephard, N., Pollard, D., Hunt, B. J., Fuller, G., Nelson-Piercy, C., Knight, M., Thomas, S., Lecky, F. & Cohen, J. (2018) Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: the DiPEP diagnostic study with decision-analysis modelling. Health Technol Assess. [Online] 22 (47), 1–230.  Available from: https://www.ncbi.nlm.nih.gov/pubmed/30178738.

Gray, J. L., Singh, G., Uttley, L. & Balasubramanian, S. P. (2018) Routine thyroglobulin, neck ultrasound and physical examination in the routine follow up of patients with differentiated thyroid cancer—Where is the evidence? Endocrine. [Online]

Image of Value in Health journal
Value in Health      
       Gray, L. A., Wailoo, A. & Hernandez, M. (2018) Mapping the FACT-B Instrument to EQ-5D-3L in Patients with Breast Cancer Using Adjusted Limited Dependent Variable Mixture Models versus Response Mapping. Value in Health. [Online]

       Henderson, C., Dixon, S., Bauer, A., Knapp, M., Morrell, C. J., Slade, P., Walters, S. J. & Brugha, T. (2018) Cost-effectiveness of PoNDER health visitor training for mothers at lower risk of depression: findings on prevention of postnatal depression from a cluster-randomised controlled trial. Psychol Med. [Online] 1–11.  Available from: https://www.ncbi.nlm.nih.gov/pubmed/30157976.

       Holmes, J., Angus, C., Meier, P. S., Buykx, P. & Brennan, A. (2018) How should we set consumption thresholds for low risk drinking guidelines? Achieving objectivity and transparency using evidence, expert judgement and pragmatism. Addiction. [Online]  Available from: https://www.ncbi.nlm.nih.gov/pubmed/30133036.

Latimer, N., Alshreef, A., Bhadhuri, A. & Palmer, R. (n.d.) Big CACTUS Health Economics Analysis Plan FINAL v2.

Maden, M., McMahon, N., Booth, A., Dickson, R., Paisley, S. & Gabbay, M. (2018) Towards a theory-led meta-framework for considering socioeconomic health inequalities within systematic reviews. Journal of Clinical Epidemiology. [Online] (0895–4356), .  Available from: https://www.ncbi.nlm.nih.gov/pubmed/30125710.

Maheswaran, R., Green, M. A., Strong, M., Brindley, P., Angus, C. & Holmes, J. (2018) Alcohol outlet density and alcohol related hospital admissions in England: a national small-area level ecological study. Addiction. [Online]
Image of PharmacoEconomics journal

Pennington, B., Hernandez-Alava, M., Pudney, S. & Wailoo, A. (2018) The Impact of Moving from EQ-5D-3L to -5L in NICE Technology Appraisals. PharmacoEconomics. [Online]

Tes, D., Aber, A., Zafar, M., Horton, L., Fotouhi, A., Xu, Q., Moiin, A., Thompson, A. D., Moraes Pinto Blumetti, T. C., Daveluy, S., Chen, W. & Nasiriavanaki, M. (2018) Granular Cell Tumor Imaging Using Optical Coherence Tomography. Biomed Eng Comput Biol. [Online] 91179597218790250–1179597218790250.  Available from: https://www.ncbi.nlm.nih.gov/pubmed/30116105.

Thursday, 13 September 2018

Website of the Month - Error Statistics Philosophy

This month's recommended website of the month was suggested by our own Dr John Stevens who is the Director of the Centre for Bayesian Statistics in Health Economics (CHEBS). 

Image of https://errorstatistics.com/ website
Dr Stevens suggests you pop over to the Error Statistics Philosophy" blog. The site is managed by Deborah May with lots of contributions from professor Stephen Senn from ScHARR's Design, Trails and Statistics section. 


Wednesday, 12 September 2018

Medtech Innovation Briefings (MIBs)…

… published since our last update in April are listed below.  The MIBs review relevant published evidence and the likely costs of new technologies. They are designed to be fast, flexible and responsive to the need for information on innovative technologies.  MIBs are commissioned by NHS England.  Further details are available here.
  • Neon EEG electrode for EEG monitoring in newborns   
  • NephroCheck test to help assess the risk of acute kidney injury in critically ill patients   
  • AlignRT in breast cancer radiotherapy   
  • Rezum for treating benign prostatic hyperplasia   
  • Mechanical thrombectomy devices for acute ischaemic stroke   
  • Remote ECG interpretation consultancy services for cardiovascular disease   
  • Airglove air warming system for venous access   
  • ORA G3 to measure corneal hysteresis   
  • PICO negative pressure wound therapy for closed surgical incision wounds   
  • VIDAvision for lung volume analysis in emphysema   
  • AlignRT for intracranial stereotactic radiosurgery   
  • QAngio XA 3D/QFR imaging software for assessing coronary obstructions   
  • Point-of-care diagnostic testing in primary care for strep A infection in sore throat   
  • Noctura 400 Sleep Mask for diabetic retinopathy and diabetic macular oedema

Thursday, 6 September 2018

HEDS 3 Day Course - ScHARR Systematic Reviews and Meta-analysis Short Course

ScHARR Systematic Reviews and Meta-analysis Short Course

3 day course:  Tuesday, 26th - Thursday, 28th March 2019

The aim of this three day course is to provide participants with an introduction to methods for conducting systematic reviews and meta-analysis in health care. Sessions will be delivered by ScHARR staff experienced in systematic review methods and health technology assessment. The course will be interactive and practical, with delivery of sessions based on lectures and individual and small group practical exercises.

Who will benefit from this course?

The course is suitable for researchers who require an introduction to methods for conducting systematic 
reviews in health care, and professionals who need to develop the ability to interpret and asses the quality of systematic reviews. The course is also suitable for:
  • Clinicians wanting to undertake their own systematic review
  • PhD Students with a significant review component to their thesis
  • Members of academic systematic review teams
  • Pharmaceutical companies and consultancies requiring an understanding of review methods
No previous knowledge of systematic reviews or meta-analysis is assumed.
This course is relevant to anyone involved in systematic reviews. If you are specifically interested in qualitative evidence synthesis only, please see our ESQUIRE course for further details.
Image of Halifax Hall
Location: Halifax Hall
Learning Outcomes
By the end of this course participants should be able to:
  • Identify the key stages of the systematic review process
  • Define a review question and understand how to develop a review protocol
  • Describe methods for identifying sources of evidence for systematic reviews
  • Develop a search strategy to identify relevant studies for a specific review question and understand how to conduct a literature search
  • Apply inclusion criteria to identify relevant studies
  • Undertake critical appraisal of evidence using standardised quality checklists
  • Develop a data extraction form and extract relevant outcomes from reported studies
  • Select appropriate methods of evidence synthesis and be able to describe and summarise key results
  • Be familiar with statistical methods for analysis of quantitative data
  • Explore the use of meta-analysis in data synthesis using computer software
  • Understand potential sources of heterogeneity between included studies
  • Be familiar with good practice in reporting of systematic reviews
  • Critically appraise a systematic review

Course Materials

Course Materials will be provided via a Delegate Course Website approximately 2 weeks prior to the course start date.  Hard copies of exercises will be provided throughout the course.  Hard copies of powerpoint presentations will not be generally provided, but these can be printed and downloaded by delegates before the start of the course via the Delegate Course Website if required.  A USB of all materials will be provided on the first day of the course during registration.
Delegates are asked to provide their own laptop to use for the duration of the course.  If this is not possible please contact us as soon as possible.


Marrissa Martyn-St James, is the course leader for this popular ScHARR short course.
Plus other members of ScHARR staff to be confirmed.

Friday, 31 August 2018

Dr Paul Tappenden as Guest Editor on themed issue of PharmacoEconomics - 'Improving transparency in decision models'

Image of Dr Paul Tappenden
Dr Paul Tappenden

Dr Paul Tappenden has taken on the role of Guest Editor for a themed issue of PharmacoEconomics on the topic of improving transparency in decision models. Details of the call are available here - https://adisintouch.com/2018/07/12/pec-cfp-july18/

PharmacoEconomics invites the submission of papers (original research, reviews and opinion pieces) on improving transparency in decision models for a themed issue of the journal to be published in 2019. Dr Tappenden will be joined by fellow guest editor Jaime Caro (London School of Economics and McGill University). We encourage papers from the perspectives of a variety of stakeholders including methodologists, payers, health technology assessment bodies, analysts, pharmaceutical industry, advocacy groups and software developers. Country-specific perspectives are also encouraged. Papers can be either methodological or applied.

Topics of interest include:
Why the need for change?
Advantages and disadvantages of transparency
What would an ideal world look like?
Challenges and solutions in moving to a more transparent world
Current open source and transparency initiatives
Software programs and hosting platforms
Economic evaluations using open source models
Methods and techniques for transparent model programming (e.g. housekeeping, colour coding, separating inputs, calculations and outputs, breaking up formulae, other approaches)
Protecting intellectual property rights and funding in an open source world

Please submit an abstract describing your proposed paper by September 30th, 2018 to chris.carswell@springer.com. Full papers will be invited by October 30th 2018 and manuscripts due early 2019.
Image of PharmaocEconomics Journal
© Adis

Wednesday, 29 August 2018

Job Vacancy - Research Associate in Health Economics and Decision Modelling

Job Reference Number: UOS020060

Job Title: Research Associate in Health Economics and Decision Modelling

Apply here

Contract Type: Fixed term for 2 years

Working Pattern: Full time

Faculty: Faculty of Medicine, Dentistry and Health

Department: School of Health and Related Research (ScHARR)

Salary: Grade 7 - £31,302 to £39,609 per annum with the potential to progress to £43,267
through sustained exceptional contribution.

Closing Date: 19th September 2018
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Regent Court
We are seeking to appoint a Research Associate in Health Economics and Decision Modelling. The post is within the Health Economics and Decision Science (HEDS) section of the School of Health and Related Research (ScHARR). You will support research and consultancy programmes in the Section of Health Economics and Decision Science (HEDS). The work will be focused on applied cost-effectiveness analysis and health economic modelling working on a range of projects and with a range of funders including NHS organisations, government bodies and agencies, healthcare and pharmaceutical companies, and research funders nationally and internationally. This will include work as part of the ScHARR Technology Appraisal Group, which conducts analyses and reviews of submissions as part of the NICE process, economic evaluation around clinical trials, and methods development work relating to any of those areas. The mix of work will be
determined both by the needs of those work programmes and the expertise and interests of the successful candidate.

You may contribute to the writing of research and consultancy proposals and conduct analyses as part of a broad portfolio of studies. You may also develop methodological work and provide associated training on those methods. You will disseminate findings in peer-reviewed journals and contribute to/ensure wider impact with decision makers. Applicants should have research experience in health economics and decision modelling. You should expect to develop existing methodological research interests, complementary to those within HEDS. You will also contribute to the development and delivery of Masters level teaching, supervision of postgraduate students and the provision of other types of training. You should have a Postgraduate qualification or equivalent in a numerate subject, for example, mathematics, operational research, statistics or economics. This post is fixed term for 2 years working full time.

We’re one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development. We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions
complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

To find out what makes the University of Sheffield a remarkable place to work, watch this short film:

Tuesday, 28 August 2018

July’s CEAs, systematic reviews and epidemiological models in LMICs

To help us keep on top of current research in low and middle-income countries, we are running a monthly search of research that is aligned to our core research interests.  It's a simple search strategy, with those published last month that are most aligned to our interests listed below.  The full list of articles is kept in our "Searches archive" in the right-hand column.
  • Alebel A, Tesma C, Temesgen B, Ferede A, Kibret GD. Exclusive breastfeeding practice in Ethiopia and its association with antenatal care and institutional delivery: a systematic review and meta-analysis. International breastfeeding journal. 2018;13:31.
  • Gomes Casavechia MT, de Melo GAN, Da Silva Fernandes ACB, De Castro KR, Pedroso RB, Da Silva Santos T, et al. Systematic review and meta-analysis on Schistosoma mansoni infection prevalence, and associated risk factors in Brazil. Parasitology. 2018;145(8):1000-14.
  • Leech AA, Kim DD, Cohen JT, Neumann PJ. Use and Misuse of Cost-Effectiveness Analysis Thresholds in Low- and Middle-Income Countries: Trends in Cost-per-DALY Studies. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 2018;21(7):759-61.
  • LeFevre A, Cabrera-Escobar MA, Mohan D, Eriksen J, Rogers D, Neo Parsons A, et al. Forecasting the Value for Money of Mobile Maternal Health Information Messages on Improving Utilization of Maternal and Child Health Services in Gauteng, South Africa: Cost-Effectiveness Analysis. JMIR mHealth and uHealth. 2018;6(7):e153.
  • Orlando S, Triulzi I, Ciccacci F, Palla I, Palombi L, Marazzi MC, et al. Delayed diagnosis and treatment of tuberculosis in HIV+ patients in Mozambique: A cost-effectiveness analysis of screening protocols based on four symptom screening, smear microscopy, urine LAM test and Xpert MTB/RIF. PloS one. 2018;13(7):e0200523.