HEDS is part of the School of Health and Related Research (ScHARR) at the University of Sheffield. We undertake research, teaching, training and consultancy on all aspects of health related decision science, with a particular emphasis on health economics, HTA and evidence synthesis.

Tuesday, 26 September 2017

EUNetHTA Magazine Autumn 2017

It includes details of recent work programme developments, use of EUNetHTA assessments in Hungary and Finland, plus a report on harmonisation of data requirements by the EMA and EUNetHTA.

Available here.

Monday, 25 September 2017

Medtech Innovation Briefings (MIBs)…

… published since our last update in April are listed below.  The MIBs review relevant published evidence and the likely costs of new technologies. They are designed to be fast, flexible and responsive to the need for information on innovative technologies.  MIBs are commissioned by NHS England.  Further details are available here.
  • Aptiva for painful diabetic neuropathy   
  • Fungitell for antifungal treatment stratification   
  • Biopatch for venous or arterial catheter sites   
  • Urethrotech UCD for difficult or failed catheterisation   
  • VEST external stent for coronary artery bypass grafts   
  • FebriDx for C-reactive protein and Myxovirus resistance protein A testing in primary care   
  • Nasal Alar SpO2 sensor for monitoring oxygen saturation by pulse oximetry   
  • Arctic Sun 5000 for therapeutic hypothermia after cardiac arrest   
  • Absorb Bioresorbable Vascular Scaffold system for coronary artery disease   
  • Aquilion PRIME CT scanner for imaging coronary artery disease in adults in whom imaging is difficult   
  • Somatom Definition Edge CT scanner for imaging coronary artery disease in adults in whom imaging is difficult   
  • L-Dex U400 for lymphoedema after breast cancer treatment   
  • FreeStyle Libre for glucose monitoring   
  • RIDASCREEN tests for monitoring infliximab in inflammatory bowel disease   
  • Neo Pedicle Screw System for spinal fusion surgery   
  • SecurAcath for securing cerebrospinal fluid catheters   
  • Bindex for investigating suspected osteoporosis   
  • Permacol for treating anal fistulae   
  • NaviCam for diagnosing gastrointestinal tract conditions   
  • Hemosep for cell salvage   
Image:  Innovation by Boegh

Friday, 22 September 2017

New Project - EUSCREEN - Implementation of optimized childhood vision and hearing screening programmes in middle-income countries in Europe

Dr Jill Carlton (ScHARR), Paolo Mazzone (ScHARR) and Dr Helen Griffiths (Academic Unit of Ophthalmology & Orthoptics) from the University of Sheffield are leading the work on evaluation of existing vision screening programmes in middle income countries in Europe.

Image of a face with a blue eye
CC BY-SA 2.0 Matteo Ferraresso
Screening for vision and hearing disorders in children has shown to be highly effective.  Early detection and treatment of amblyopia prevents lifelong visual impairment. Early detection and treatment of hearing impairment prevents delayed speech and language development.  Across Europe inequity exists in the provision of childhood vision and hearing screening programmes. High-Income Countries (HICs) have vision and hearing screening programmes, but these vary widely, making it difficult for healthcare providers and policy-makers to decide what screening to implement in Low- to Middle-Income Countries (LMICs) and how.

In this study, a cost-effectiveness model will be used to establish the optimal screening regime for any particular set of local or national circumstances. Screening programme data will be gathered across 41 European countries. Cost-optimised, evidence-based screening will then be implemented in two LMICs, based on collated evidence from existing vision and hearing screening programmes in Europe. 

A generic strategy for implementation will be developed, and alongside lessons learnt from the implementation studies, a transferable Toolkit will be created. The Toolkit will assist healthcare providers and policy-makers in their decisions to introduce or modify screening programmes, to increase effectiveness, efficiency and equity of child healthcare. The project is funded by Horizon2020.  Further details can be found https://www.euscreen.org/

Wednesday, 20 September 2017

HEDS Modelling and economics jobs

We are currently recruiting to two posts.  Both relate to research using applied cost-effectiveness analysis and methods development across a range of research projects.  The key difference is that one is more focussed on modelling and undertaking work for NICE as part of their Technology Appraisal Programme.  Whilst the other will have a greater emphasis on randomised controlled trials, health outcomes with simpler decision analytic modelling.
  • The first post is “Health Economics and Decision Modelling” and more details can be found here.
  • The second post is “Health Economics” and more details can be found here.
Both are for either a Research Associate or a Research Fellow.  Both have a closing date of 11th October 2017.

Image:  Work. by Anthony Auston

Monday, 18 September 2017

HEDS Special lecture

On Tuesday 19th September, Professor Karen Hofman will be giving a lecture titled “Progress and challenges in implementing Health Technology Assessment and Public Health Economics in LMICs: the experience in South Africa”

The lecture is from 11:00am to noon, in Seminar Room 117, Jessop Building.

Want to know more?  Here’s a summary of what Karen will be talking about:

Prof Karen Hofman, is founder and director of PRICELESS SA  ( priority cost effective lessons for systems strengthening South Africa) based at the Wits School of Public Health in Johannesburg, will discuss the basis for establishing this vibrant research to policy unit, and an overview of the current program of research by her multidisciplinary team. Their work is focused on how scarce resources can best be deployed to ensure improved health and better care in the public health system. She will focus on some successful policy engagements, including work on salt regulations and the proposed sugary beverage tax as well as setting priorities for maternal and child health. Karen's presentation will include promising developments and challenges with regard to HTA in the journey towards universal health coverage in South Africa.

Thursday, 14 September 2017

August’s CEAs, systematic reviews and epidemiological models in LMICs

To help us keep on top of current research in low and middle-income countries, we are running a monthly search of research that is aligned to our core research interests.  It's a simple search strategy, with those published in August that are most aligned to our interests listed below.  The full list of articles is kept in our "Searches archive" in the right-hand column.
  • Damian DJ, Njau B, Lisasi E, Msuya SE, Boulle A. Trends in maternal and neonatal mortality in South Africa: a systematic review protocol. Systematic reviews. 2017;6(1):165.
  • Horton S, Gelband H, Jamison D, Levin C, Nugent R, Watkins D. Ranking 93 health interventions for low- and middle-income countries by cost-effectiveness. PloS one. 2017;12(8):e0182951.
  • James R, Khim K, Boudarene L, Yoong J, Phalla C, Saint S, et al. Tuberculosis active case finding in Cambodia: a pragmatic, cost-effectiveness comparison of three implementation models. BMC infectious diseases. 2017;17(1):580.
  • Morais DC, Moraes LFS, Silva D, Pinto CA, Novaes JF. Methodological aspects of dietary quality assessment in Brazil: systematic review. Ciencia & saude coletiva. 2017;22(8):2671-80.
  • Ngalesoni F, Ruhago G, Mayige M, Oliveira TC, Robberstad B, Norheim OF, et al. Cost-effectiveness analysis of population-based tobacco control strategies in the prevention of cardiovascular diseases in Tanzania. PloS one. 2017;12(8):e0182113
Image: Research by Thomas Haynie

Tuesday, 12 September 2017

August’s CEAs.....

Our quick search for CEA’s published in July uncovered 41 articles.   In the right-hand column of this blog is a CEA Archive, which includes our CEA search results by month.  Below are those in our areas of interest.
  • Cohen JT, Neumann PJ, Wong JB. A Call for Open-Source Cost-Effectiveness Analysis. Annals of internal medicine. 2017.
  • Cromer D, van Hoek AJ, Newall AT, Pollard AJ, Jit M. Burden of paediatric respiratory syncytial virus disease and potential effect of different immunisation strategies: a modelling and cost-effectiveness analysis for England. The Lancet Public health. 2017;2(8):e367-e74.
  • Lindemark F, Haaland OA, Kvale R, Flaatten H, Norheim OF, Johansson KA. Costs and expected gain in lifetime health from intensive care versus general ward care of 30,712 individual patients: a distribution-weighted cost-effectiveness analysis. Critical care (London, England). 2017;21(1):220.
  • Meulen MPV, Kapidzic A, Leerdam MEV, van der Steen A, Kuipers EJ, Spaander MCW, et al. Do Men and Women Need to Be Screened Differently with Fecal Immunochemical Testing? A Cost-Effectiveness Analysis. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2017;26(8):1328-36.
  • Russell LB, Bhanot G, Kim SY, Sinha A. Using Cluster Analysis to Group Countries for Cost-Effectiveness Analysis: An Application to Sub-Saharan Africa. Medical decision making : an international journal of the Society for Medical Decision Making. 2017:272989x17724773.

Monday, 11 September 2017

New DSU report….

….Methods for mapping between the EQ-5D-5L and the 3L for technology appraisal.  By Monica Hernandez Alava, Allan Wailoo and Stephen Pudney.

Anyone reading this report should also read the NICE position statement on the EQ-5D-5L published recently and reported in the HEDS Blog.

Image: Report Key by GotCredit

Friday, 8 September 2017

New Project - Scalable behavioural weight management programmes for the prevention and treatment of diabetes

HEDS are collaborating on a new project   'Scalable behavioural weight           management programmes for the   prevention and treatment of diabetes'.

Research Associate Penny Breeze said of the project: "Behavioural weight management programmes (BWMPs) can help prevent type 2 diabetes (T2D) and help people who have type 2 diabetes achieve normal blood sugar (glucose) levels and reduce the need for medication. However, programmes delivered by specialist health professionals in clinical settings are too expensive to deliver to everyone who needs them."
Image of Scrabble letters spelling the word Diabetes
CC BY 2.0 Practical Cures http://bit.ly/2vFxMTR                        

"First we will evaluate existing group-based weight loss programmes that use non-specialists and technology to increase reach. Second, we will use our findings to develop a new BWMP that targets the reasons people struggle to maintain weight loss, and that can be delivered in groups by trained non-specialists  using technology. We will work with patients and practitioners to develop the programme so that it meets the needs of both. We will then evaluate its feasibility and acceptability and estimate potential effects."

Thursday, 7 September 2017

Latest Publications from HEDS in August

Our regular monthly trawl for new publications from HEDS in collaboration with colleagues in ScHARR and further afield has reaped a tremendous amount of fresh research. Many of these are currently in press, so you can find much of our work in its open access form via our institutional repository. Tuck in here.   

Aber, A., Poku, E., Phillips, P., Essat, M., Buckley Woods, H., Palfreyman, S., Kaltenthaler, E., Jones, G., Michaels, J., 2017. Systematic review of patient-reported outcome measures in patients with varicose veins. British Journal of Surgery. doi:10.1002/bjs.10639

© SAGE Journals
Ali, S., Tsuchiya, A., Asaria, M., Cookson, R., 2017. How Robust Are Value Judgments of Health Inequality Aversion? Testing for Framing and Cognitive Effects. Medical Decision. Making. 37, 635–646. doi:10.1177/0272989X17700842

Aslam, R.W., Hendry, M., Booth, A., Carter, B., Charles, J.M., Craine, N., Edwards, R.T., Noyes, J., Ntambwe, L.I., Pasterfield, D., Rycroft-Malone, J., Williams, N., Whitaker, R., 2017. Intervention Now to Eliminate Repeat Unintended Pregnancy in Teenagers (INTERUPT): a systematic review of intervention effectiveness and cost-effectiveness, and qualitative and realist synthesis of implementation factors and user engagement. BMC Medicine 15, 155. doi:10.1186/s12916-017-0904-7

Chambers, D., Booth, A., Rodgers, M., Preston, L., Baxter, S., Dalton, J., Thomas, S., Johnson, M., Goyder, E., Parker, G., Street, A., Eastwood, A., 2017. NIHR HS&DR evidence synthesis centres: achievements and learning from the first three year programme, 2014–2017. NIHR Health Services and Delivery Research Programme, Southampton.

Grimm, S.E., Strong, M., Brennan, A., wailoo, A., n.d. The HTA Risk Analysis Chart: Visualising the Need for and Potential Value of Managed Entry Agreements in Health Technology Assessment. Pharmacoeconomics.

Image of Health Economics Journal
© Wiley
Johannesen, K.M., Claxton, K., Sculpher, M.J., Wailoo, A.J., n.d. How to design the cost-effectiveness appraisal process of new healthcare technologies to maximise population health: A conceptual framework. Health Economics. doi:10.1002/hec.3561

Keetharuth, D., Brazier, J., Connell, J., Bjorner, J., Carlton, J., Taylor Buck, E., Ricketts, T., McKendrick, K., Browne, J., Croudace, T., Barkham, M., n.d. Recovering Quality of Life (ReQoL): a new generic self-reported outcome measure for use with people experiencing mental health difficulties. British Journal of Psychiatry.

Lysdahl, K.B., Mozygemba, K., Burns, J., Brönneke, J.B., Chilcott, J.B., Ward, S., Hofmann, B., 2017. Comprehensive assessment of complex technologies: integrating various aspects in health technology assessment. International Journal of Technology Assessment in Health Care. doi:10.1017/S0266462317000678

Preston, L.R., Chambers, D., Campbell, F., Cantrell, A., Turner, J., Goyder, E., 2017. What evidence is there for the identification and management of frail older people in the emergency department? A systematic mapping review. NIHR Journals Library, Southampton.

Image of PharmacoEconomics journal cover
© Springer Science
Simpson, E.L., Hock, E., Stevenson, M., Wong, R., Dracup, N., Wailoo, A., Conaghan, P.G., Estrach, C., Edwards, C.J., Wakefield, R.J., n.d. What is the added value of ultrasound joint examination for monitoring synovitis in rheumatoid arthritis and can it be used to guide treatment decisions? A systematic review and cost-effectiveness analysis. Health Technol. Assess.

Squires, H., Pandor, A., Thokala, P., Stevens, J.W., Kaltenthaler, E., Clowes, M., Coleman, R., Wyld, L., 2017. Pertuzumab for the Neoadjuvant Treatment of Early-Stage HER2-Positive Breast Cancer: An Evidence Review Group Perspective of a NICE Single Technology Appraisal. Pharmacoeconomics. doi:10.1007/s40273-017-0556-7

Squires, H.Y., Poku, E., Bermejo, I., Cooper, K., Stevens, J., Hamilton, J., Wong, R., Denniston, A., Pearce, I., Quhill, F., n.d. A systematic review and economic evaluation of adalimumab and dexamethasone for treating non-infectious intermediate, posterior or panuveitis in adults. Health Technol. Assess.