The primary objective of these methodology guidelines is to focus on methodological challenges that are encountered by HTA assessors while performing a rapid relative effectiveness assessment of pharmaceuticals. In total, 9 guidelines on methodological issues are being produced:
Clinical endpoints;
Composite endpoints;
Surrogate endpoints;
Safety;
Health related quality of life (HRQoL);
Criteria for the choice of the most appropriate comparator(s);
Direct and indirect comparisons;
Internal validity;
Applicability.
The current consultation covers topics 2, 3, 6 and 9 and is open between 29 June and 10 September 2012. The next public consultation for remaining topics is planned to be held between August 27 and October 30, 2012.